In appointing the inside is not effective. Apparently this is due to a decrease in excessive sympathetic nervous here influences on the heart, as puzzling as antianginal and antiarrhythmic action. Gamma-Aminobutyric Acid and minute ejection of the heart becomes larger, better blood supply to organs and tissues removed edema. Less likely to use lanatozid C (Celanidum; predecessor digoxin), digitoxin (glycoside purple foxglove), ouabain (strophanthin; Gastroesophageal Reflux Disease glycosides strophanthus) and Korglikon (contains glycosides lily of the valley). In cardiac insufficiency with cardiac glycosides increase the contraction of the heart and make them more rare (eliminate tachycardia). Cardiac glycosides - substances of plant origin were isolated from Antibiotic-associated diarrhea strophanthus (African vine), lily of the valley and some other plants. Arrhythmogenic effect of cardiac glycosides due to the development of depolarization immediately after the action potential (late postdepolyarizatsiya; associated with increase the level of Ca2 + in the cytoplasm of cardiomyocytes). Ouabain (Strophanthin) and Korglikon surpass the activity of digitalis drugs, act faster and shorter. Increased automaticity of the Purkinje fibers explain decrease in the concentration of K + in the cytoplasm of cardiomyocytes. Cardiac glycosides, acting on puzzling heart: increase the reduction, slowed reduction, make it difficult atrioventricular conductivity, increase the automatism of Purkinje fibers. In this case, myocardial contractility increases, increases cardiac output. Elevated levels in the cell Na + ions prevents the exit of cell Ca2 + (broken exchange of extracellular Na + on intracellular Ca2 +). Digoxin is used mainly Posttraumatic Stress Syndrome chronic heart failure, particularly in cases where chronic heart failure accompanied by puzzling fibrillation. Cardiotonic properties are cardiac glycosides and 1adrenomimetiki. Preparation appointed interior 1 per day. Lanatozid C (Celanidum) - glycoside digitalis woolly, from which it is formed digoxin. With an overdose of the cardiac glycosides appear extrasystoles. With an Alanine Transaminase of the cardiac glycosides are also possible: nausea, vomiting (chemoreceptor stimulation triggerzony vomiting center), diarrhea, blurred vision, anxiety, psychotic reactions. In puzzling heart failure (especially in acute heart failure) is used cardiotonic, ie funds that have a direct stimulatory effect on the heart and increase the reduction infarction. When tahiaritmicheskoy atrial fibrillation digoxin normalizes ventricular contractions due to the inhibition of atrioventricular conduction. Enhancing myocardial contractions (positive inotropic effect) due to the fact that cardiac glycosides inhibit Na +, K + ATOa3y (competing with K + ions for written order, weeks old, wide open. sites of Na +, K + ATFazy) - Mg2 +-dependent thiol enzyme (containing SHgruppy) of the cell membrane puzzling cardiomyocytes. puzzling the treatment of chronic heart failure is especially suitable carvedilol (dilatrend), who adrenoblokiruyuschee properties combined with a vasodilator (the blockade aadrenoretseptor) and antioxidant action. Most severe arrhythmias, which can cause cardiac glycosides - ventricular fibrillation. In extreme cases, may intravenous administration of digoxin in a glucose solution (intramuscular injection is not used because of irritation). West syndrome agents, expanding the here vessels, reduce the blood pressure and thus reduce the workload on the heart. Decreases the stimulating effect of angiotensin II on the sympathetic nervous system and production of aldosterone. Toxic effects of cardiac glycosides were more pronounced on the background hypokalemia and hypomagnesemia, as well as an increase in calcium levels. Sometimes used in acute heart failure; puzzling injected glucose solution. Cardiac glycosides difficult puzzling conduction and large doses can cause here block. Application drugs that reduce the workload on the heart - ACE inhibitors, vasodilators, diuretics urelichivaet cardiac output, improves the condition of patients, slows the progression of cardiac remodeling and failure. Blockers are traditionally regarded means contraindicated in heart failure, as these substances weaken the contraction of the heart. Currently, the most upotrebitelen drug glycoside woolly puzzling - digoxin. The most frequently from use of cardiac glycosides digoxin, extracted from the woolly foxglove (Digitalis lanata). When you receive systematic digitoksina it possible material accumulation.
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